WO but for xenos. I'm on phone so il be short with this, but if people like the idea il go further into detail later.
Xeno hive busts out of containment on a weyland research facility, they make passage ways throughout it, take over monkey spawners, and build defenses. Weyland sends in recontainment synths, first unarmed to coax the aliens back to the hive, then with nonlethal weapons to "coax", then at the end a full 4 member synth deathsquad to exterminate the hive. There would be different things the synths can do to make it easier, but require time to activate or deactivate, so xenos would have to combo protecting the always stationary queen, and making sure the synths aren't allowed to get to key points around the map, giving xenos the same feeling as defending marines on WO, where the situation can snowball quickly.